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LB42708
Artikelnummer: TGM-T2678-100mg
Description: LB42708 is an orally active farnesyltransferase (FTase) inhibitor (IC50: 0.8/1.2/2.0 nM toward H/N/K-ras). Target: Transferase. Smiles: C(=O)(C=1C(=CN(CC=2N(CC3=CC=C(Br)C=C3)C=NC2)C1)C=4C5=C(C=CC4)C=CC=C5)N6CCOCC6. References: Na HJ, et al. J Immunol. 2004, 173(2), 1276-1283.
| Anwendung: | FTase inhibitor |
| CAS | 226929-39-1 |
| MW: | 555.47 D |
ab 42,00 €
LB 42708
Artikelnummer: Cay16428-5
Farnesylation, the post-translational addition of a 15-carbon isoprenyl group, alters the function of several proteins, including Ras proteins. LB 42708 is a potent inhibitor of farnesyltransferase (FTase), blocking farnesylation of H-Ras, N-Ras, and K-Ras4B with IC50 values of 0.8, 1.2, and 2.0 nM, respectively. It...
| Schlagworte: | [1-[[1-[(4-bromophenyl)methyl]-1H-imidazol-5-yl]methyl]-4-(1-naphthalenyl)-1H-pyrrol-3-yl]-4-morpholinyl-methanone |
| Anwendung: | FTase inhibitor |
| CAS | 226929-39-1 |
| MW: | 555.5 D |
ab 60,00 €
