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NEU
AZD 4604
Artikelnummer: Cay39890-10
AZD 4604 is a JAK1 inhibitor (IC50 = 0.54 nM). It is selective for JAK1 over JAK2 and JAK3 (IC50s = 686 and >10,000 nM, respectively), as well as tyrosine kinase 2 (TYK2, IC50 = 657 nM). AZD 4604 inhibits IL-4- or IL-13-induced phosphorylation of STAT6 in U937 cells (IC50s = 24 and 34 nM, respectively). In vivo, AZD...
| Schlagworte: | Londamocitinib,... |
| Anwendung: | JAK1 inhibitor |
| CAS | 2241039-81-4 |
| MW: | 599.7 D |
ab 35,00 €
Londamocitinib
Artikelnummer: TGM-T11706-100mg
Description: Londamocitinib (JAK1-IN-7) is a selective and potent JAK1 inhibitor with anti-inflammatory activity. Target: JAK. Smiles: COC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1F. References: NILSSON, Karl, Magnus, et al. Jak1 selective inhibitors. WO2018134213A1.
| Schlagworte: | AZD4604 |
| CAS | 2241039-81-4 |
| MW: | 599.65 D |
ab 187,00 €
