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MS1943
Artikelnummer: TGM-T13780-100mg
Description: MS1943 is a orally bioavailable EZH2 selective degrader(IC50 of 120 nM). Target: Histone Methyltransferase, Apoptosis. Smiles: CC(C)n1ncc2c(cc(cc12)-c1ccc(nc1)N1CCN(CCNC(=O)CC23CC4CC(CC(C4)C2)C3)CC1)C(=O)NCc1c(C)cc(C)[nH]c1=O. References: Ma A, et al. Discovery of a first-in-class EZH2 selective...
| Anwendung: | EZH2 degradation driving PROTAC |
| CAS | 2225938-17-8 |
| MW: | 718.93 D |
ab 55,00 €
MS1943
Artikelnummer: Cay35466-1
MS1943 is a proteolysis-targeting chimera (PROTAC) that contains the selective enhancer of zeste homolog 2 (EZH2) inhibitor C24 linked to an adamantyl group. It inhibits EZH2 (IC50 = 120 nM) and is selective for EZH2 over EZH1, as well as a panel of 45 kinases at 10 µM. MS1943 (4 µM) induces EZH2 degradation and...
| Schlagworte: | N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[6-[4-[2-[(2-tricyclo[3.3.1.13,7]dec-1-ylacetyl... |
| Anwendung: | EZH2 degradation driving PROTAC |
| CAS | 2225938-17-8 |
| MW: | 718.9 D |
ab 44,00 €
