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AG-270
Artikelnummer: TGM-T9050-100mg
Description: AG-270 is an allosteric and orally active inhibitor of MAT2A. Target: Others, Methionine Adenosyltransferase (MAT). Smiles: COc1ccc(cc1)-c1c(Nc2ccccn2)[nH]c2c(c(nn2c1=O)-c1ccccc1)C1=CCCCC1. References: Zenon Konteatis, et al. Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment...
| Anwendung: | MAT2A (S-adenosylmethionine synthetase) inhibitor |
| CAS | 2201056-66-6 |
| MW: | 489.57 D |
ab 112,00 €
AG-270
Artikelnummer: Cay36246-10
AG-270 is an inhibitor of methionine adenosyltransferase 2A (MAT2A, IC50 = 0.014 µM). It reduces levels of S-(5'-adenosyl)-L-methonine (SAM, Cay-16376, Cay-17595) in, and inhibits the proliferation of, HCT116 cells with a homozygous deletion of MTAP, the gene encoding methylthioadenosine phosphorylase (IC50s = 0.2...
| Schlagworte: | 3-(1-cyclohexen-1-yl)-6-(4-methoxyphenyl)-2-phenyl-5-(2-pyridinylamino)-pyrazolo[1,5-a]pyrimidin-7(4H)-one |
| Anwendung: | MAT2A (S-adenosylmethionine synthetase) inhibitor |
| CAS | 2201056-66-6 |
| MW: | 489.6 D |
ab 305,00 €
