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WHI-P258
Artikelnummer: TGM-T2035-100mg
Description: WHI-P258 is a dimethoxyquinazoline inhibitor of JAK3. This compound binds JAK3 weakly and may be used as a JAK-binding negative control in the development of new therapeutics. Target: JNK, JAK, EGFR. Smiles: COC1=CC2=NC=NC(NC3=CC=CC=C3)=C2C=C1OC. References: Fry DW, et al. Science. 1994, 265(5175),...
| Anwendung: | Negative control (JAK3 inhibition) |
| CAS | 21561-09-1 |
| MW: | 281.31 D |
ab 30,00 €
WHI-P258
Artikelnummer: Cay23453-5
WHI-P258 is a quinazoline compound that modeling studies suggested would bind to the active site of JAK3 with an estimated Ki value of 72 µM. However, it is inactive at JAK3 (IC50 = >300 µM) and has been used as a negative control for structurally similar compounds that inhibit platelet aggregation and herpes...
| Schlagworte: | 6,7-dimethoxy-N-phenyl-4-quinazolinamine |
| Anwendung: | Negative control (JAK3 inhibition) |
| CAS | 21561-09-1 |
| MW: | 281.3 D |
ab 102,00 €
