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SB-02024
Artikelnummer: Cay41231-1
SB-02024 is an inhibitor of vacuolar protein sorting 34 (VPS34, IC50 = 5 nM). It selectively binds to VPS34 (Kd = 0.0011 µM) over eight other PI3K kinases (Kds = 1.2693->30 µM), mTOR (Kd = 1.0199 µM), a panel of 468 kinases at 1 µM, and an additional panel of 97 kinases at 1 µM. SB-02024 (0.7 µM) inhibits autophagic...
| Schlagworte: | 4-[(3R)-3-methyl-4-morpholinyl]-6-[(2R)-2-(trifluoromethyl)-1-piperidinyl]-2(1H)-pyridinone |
| Anwendung: | VPS34 inhibitor |
| CAS | 2126737-28-6 |
| MW: | 345.4 D |
ab 153,00 €
SB02024
Artikelnummer: TGM-T69888-100mg
Description: SB02024 is a VPS34 inhibitor. SB02024 activates cGAS-STING signaling and sensitizes tumors to STING agonist. SB02024 blocked autophagy in vitro and reduced xenograft growth of two breast cancer cell lines, MDA-MB-231 and MCF-7, in vivo. Vps34 inhibitor significantly potentiated cytotoxicity of Sunitinib...
| CAS | 2126737-28-6 |
| MW: | 345.36 D |
ab 1.521,00 €
