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Asciminib Hydrochloride
Artikelnummer: LKT-A724092.1
Asciminib is an orally bioavailable, allosteric Bcr-Abl1 tyrosine kinase inhibitor, with antineoplastic activity. Upon administration, asciminib targets and binds to the myristoyl pocket of the Bcr-Abl1 fusion protein at a location that is distinct from the ATP-binding domain, thereby inhibiting the activity of both...
| Schlagworte: | ABL001 Hydrochloride, ABL001 HCl, Scemblix, ABL001-AAA, C5U34S9XFV,... |
| Anwendung: | Allosteric ABL inhibitor, STAMP inhibitor |
| CAS | 2119669-71-3 |
| MW: | 486.3 D |
ab 137,00 €
Asciminib hydrochloride
Artikelnummer: TGM-T63226-10mg
Description: Asciminib (ABL001) hydrochloride is a selective, potent inhibitor of mutant BCR-ABL1, effectively inhibiting Ba/F3 cell growth with an IC50 of 0.25 nM. Target: Others. Smiles: Cl.O[C@@H]1CCN(C1)c1ncc(cc1-c1cc[nH]n1)C(=O)Nc1ccc(OC(F)(F)Cl)cc1
| Anwendung: | Targets abelson tyrosine-protein kinase 1 [EC:2.7.10.2] (ABL1) |
| CAS | 2119669-71-3 |
| MW: | 486.3 D |
ab 77,00 €
