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ARQ 531
Artikelnummer: TGM-T14323-100mg
Description: ARQ-531 is a potent and orally active BTK inhibitor with potential antineoplastic activity, with IC50s of 0.85 nM and 0.39 nM for WT-BTK and C481S-BTK, respectively. Target: BTK. Smiles: OC[C@@H]1CC[C@H](CO1)Nc1ncnc2[nH]cc(C(=O)c3ccc(Oc4ccccc4)cc3Cl)c12. References: S Eathiraj, et al. Targeting...
| Anwendung: | Targets Bruton agammaglobulinemia tyrosine kinase [EC:2.7.10.2] (BTK) |
| CAS | 2095393-15-8 |
| MW: | 478.93 D |
ab 53,00 €
ARQ 531
Artikelnummer: Cay30165-1
ARQ 531 is an inhibitor of Bruton's tyrosine kinase (BTK, IC50 = 0.85 nM). It reduces the viability of, and inhibits BTK autophosphorylation in, OCI-AML-2 acute myeloid leukemia (AML) cells when used at concentrations of 0.3 and 1 µM. In vivo, ARQ 531 (75 mg/kg) reduces tumor growth in an SU-DHL-4 B cell lymphoma...
| Schlagworte: | MK-1026, Nemtabrutinib,... |
| Anwendung: | BTK inhibitor |
| CAS | 2095393-15-8 |
| MW: | 478.9 D |
ab 35,00 €
