Zu "2089288-03-7" wurden 2 Artikel gefunden!
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azd1390
Artikelnummer: TGM-T5175-100mg
Description: AZD1390 is an exceptionally potent inhibitor of ATM in cells (IC50: 0.78 nM) with >10,000-fold selectivity over closely related members of the PIKK family of enzymes. Target: ATM/ATR. Smiles: CC(C)n1c2c(cnc3cc(F)c(cc23)-c2ccc(OCCCN3CCCCC3)nc2)n(C)c1=O. References: Durant ST, et al. The brain-penetrant...
| Anwendung: | ATM kinase inhibitor |
| CAS | 2089288-03-7 |
| MW: | 477.57 D |
ab 78,00 €
AZD 1390
Artikelnummer: Cay36498-1
AZD 1390 is an inhibitor of Ataxia-telangiectasia mutated (ATM) kinase (IC50 = 0.78 nM). It is selective for ATM over Ataxia-telangiectasia and Rad3-related protein/kinase (ATR), PI3K, mammalian target of rapamycin (mTOR), and DNA protein kinase (DNA-PK, IC50s = >30, >12, >16, and >29.9 µM, respectively). AZD 1390...
| Schlagworte: | 7-fluoro-1,3-dihydro-3-methyl-1-(1-methylethyl)-8-[6-[3-(1-piperidinyl)propoxy]-3-pyridinyl]-2H-imidazo[4,5-c]quinolin-2-one |
| Anwendung: | ATM kinase inhibitor |
| CAS | 2089288-03-7 |
| MW: | 477.6 D |
ab 68,00 €
