Zu "2088323-16-2" wurden 2 Artikel gefunden!
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TAS0728
Artikelnummer: TGM-T7819-100mg
Description: TAS0728 is a HER2 inhibitor, with antitumor activity. Target: HER, EGFR. Smiles: CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(C)c1C. References: Irie H, Ito K, Fujioka Y,et al.TAS0728, A Covalent-binding, HER2-selective Kinase Inhibitor Shows Potent Antitumor Activity in...
| Anwendung: | Covalent HER2 inhibitor |
| CAS | 2088323-16-2 |
| MW: | 504.58 D |
ab 71,00 €
TAS 0728
Artikelnummer: Cay33528-5
TAS 0728 is a covalent HER2 inhibitor (IC50 = 36 nM). It is selective for HER2 over panels of 386 and 374 additional kinases, as well as a panel of 68 non-kinase enzymes, when used at a concentration of 1 µM. TAS 0728 inhibits HER2 autophosphorylation in HER2-overexpressing SK-BR-3 cells but not autophosphorylation...
| Schlagworte: | 4-amino-N-[4-[2-(dimethylamino)-2-oxoethyl]-2,3-dimethylphenyl]-1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-1H-pyrazolo... |
| Anwendung: | Covalent HER2 inhibitor |
| CAS | 2088323-16-2 |
| MW: | 504.6 D |
ab 115,00 €
