Zu "2003234-63-5" wurden 2 Artikel gefunden!
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(R)-GNE-140
Artikelnummer: TGM-T4295-100mg
Description: (R)-GNE-140 (GNE-140) is an effective LDHA/LDHB inhibitor (IC50s: 3/5 nM) and is 18-fold more potent than S enantiomer. Target: Dehydrogenase. Smiles: OC1=C(Sc2ccccc2Cl)C(=O)N[C@@](C1)(c1ccsc1)c1ccc(cc1)N1CCOCC1. References: Purkey HE, et al. Cell Active Hydroxylactam Inhibitors of Human Lactate...
| Schlagworte: | GNE-140 |
| Anwendung: | LDHA/LDHB inhibitor |
| CAS | 2003234-63-5 |
| MW: | 499.04 D |
ab 67,00 €
GNE-140
Artikelnummer: Cay39015-10
GNE-140 is an inhibitor of lactate dehydrogenase A (LDHA) and LDHB (IC50s = 3 and 5 nM, respectively). It reduces lactate production in MiaPaCa-2 pancreatic cancer cells (IC50 = 670 nM). GNE-140 decreases proliferation in a panel of 37 cancer cell lines when used at a concentration of 5 µM.Formal Name:...
| Schlagworte: | 3-[(2-chlorophenyl)thio]-5,6R-dihydro-4-hydroxy-6-[4-(4-morpholinyl)phenyl]-6-(3-thienyl)-2(1H)-pyridinone |
| Anwendung: | LDHA/LDHB inhibitor |
| CAS | 2003234-63-5 |
| MW: | 499 D |
ab 130,00 €
