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PQR530
Artikelnummer: TGM-T16567-100mg
Description: PQR530 is a highly potent dual pan-PI3K/mTORC1/2 inhibitor. PQR530 inhibited protein kinase B (PKB, pSer473) and ribosomal protein S6 (pS6, pSer235/236) phosphorylation with IC50 values of 0.07 µM. It also showing antitumor activity. Target: mTOR, PI3K. Smiles:...
| Schlagworte: | PQR-530 |
| Anwendung: | PI3Kalpha / mTOR dual inhibitor |
| CAS | 1927857-61-1 |
| MW: | 407.42 D |
ab 48,00 €
PQR530
Artikelnummer: Cay28563-1
PQR530 is a dual inhibitor of PI3Kalpha and mammalian target of rapamycin (mTOR, IC50s = 11.1 and 7.4 nM, respectively). It inhibits phosphorylation of Akt and ribosomal S6 kinase in A2058 melanoma cells (IC50s = 62.2 and 61.1 nM, respectively). PQR530 inhibits cell growth in a panel of 66 cancer cell lines (mean...
| Schlagworte: | 4-(difluoromethyl)-5-[4-[(3S)-3-methyl-4-morpholinyl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-2-pyridinamine |
| Anwendung: | PI3Kalpha / mTOR dual inhibitor |
| CAS | 1927857-61-1 |
| MW: | 407.4 D |
ab 115,00 €
