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Lenalidomide
Artikelnummer: TGM-T1642-100mg
Description: Lenalidomide (CC-5013) is an immunomodulator with oral activity. Lenalidomide is a ligand for the ubiquitin E3 ligase cereblon (CRBN), which selectively ubiquitinates and degrades two lymphoid transcription factors, IKZF1 and IKZF3, via the CRBN-CRL4 ubiquitin ligase, and is commonly used in the...
| Schlagworte: | CC-5013 |
| Anwendung: | Targets tumor necrosis factor superfamily, member 2 (TNF, TNFA) |
| CAS | 191732-72-6 |
| MW: | 259.26 D |
ab 37,00 €
Lenalidomide
Artikelnummer: Cay14643-100
Lenalidomide is a derivative of the immunomodulatory compound thalidomide (Cay-14610). It reduces TNF-alpha production in isolated human peripheral blood mononuclear cells (PBMCs) and whole blood stimulated by LPS from S. minnesota (Cay-23608, IC50s = 13 and 25 nM, respectively). Lenalidomide has been used as a...
| Schlagworte: | Revlimid, 3-(4-amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione |
| Anwendung: | Thalidomide analog, TNF-alpha inhibitor |
| CAS | 191732-72-6 |
| MW: | 259.3 D |
ab 209,00 €
Lenalidomide
Artikelnummer: LKT-L1852.100
A thalidomide derivative that has anti-cancer properties due to its T cell co-stimulatory, anti-angiogenic and anti-inflammatory as well as apoptotic effects.
| Schlagworte: | CC-5013, Revlimid |
| CAS | 191732-72-6 |
| MW: | 259.26 D |
ab 73,00 €
Lenalidomide
Artikelnummer: BPS-82005
Lenalidomide is used to treat multiple myeloma through the interaction with the ubiquitin E3 ligase cereblon, which leads to the degradation of the Ikaros transcription factors IKZF1 and IKZF3. This indicates that the major action of lenalidomide is to re-target the activity of an enzyme rather than block the...
| Anwendung: | Protac(R) reagent |
| CAS | 191732-72-6 |
| MW: | 259,3 D |
656,00 €
