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A-485
Artikelnummer: TGM-T14073-100mg
Description: A-485 is a potent and selective catalytic p300/CBP inhibitor with IC50 values of 9.8 nM for p300 and 2.6 nM for CBP. Target: Epigenetic Reader Domain, Histone Acetyltransferase. Smiles: CNC(=O)Nc1ccc2c(CC[C@@]22OC(=O)N(CC(=O)N(Cc3ccc(F)cc3)[C@@H](C)C(F)(F)F)C2=O)c1. References: Lasko LM, et al....
| Anwendung: | p300/CBP inhibitor |
| CAS | 1889279-16-6 |
| MW: | 536.48 D |
ab 88,00 €
A-485
Artikelnummer: Cay24119-1
A-485 is an inhibitor of the histone acetyltransferase p300/CBP (IC50 = 60 nM). It decreases acetylated histone H3 lysine 27 (H3K27Ac), but not H3K9Ac, levels in PC3 cells in a concentration-dependent manner. A-485 reduces proliferation of non-small cell lung cancer (NSCLC), small cell lung cancer, triple-negative...
| Schlagworte: | (1R)-N-[(4-fluorophenyl)methyl]-2,3-dihydro-5-[[(methylamino)carbonyl]amino]-2',4'-dioxo-N-[(1S)-2,2,2-trifluoro-1-methyle... |
| Anwendung: | p300/CBP inhibitor |
| CAS | 1889279-16-6 |
| MW: | 536.5 D |
ab 67,00 €
