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ZLD1039
Artikelnummer: TGM-T29231-10mg
Description: ZLD1039 is a potent, orally bioavailable EZH2 (Enhancer of Zeste Homolog 2) inhibitor with high selectivity. It demonstrates strong, concentration-dependent inhibition of both wild-type and mutant (Y641F and A677G) PRC2 (Polycomb Repressive Complex 2) enzymatic activities, exhibiting IC50 values of 5.6,...
| Schlagworte: | ZLD 1039, ZLD-1039 |
| Anwendung: | EZH2 inhibitor |
| CAS | 1826865-46-6 |
| MW: | 612.8 D |
ab 33,00 €
ZLD1039
Artikelnummer: Cay19218-1
ZLD1039 is an inhibitor of enhancer of zeste homolog 2 (EZH2, IC50 = 5.6 nM). It is selective for EZH2 over EZH1 (IC50 = 81 nM) and is greater than 4,700-fold selective for EZH2 in a panel of 14 histone methyltransferases. ZLD1039 also inhibits mutant Y641F and A677G EZH2 (IC50s = 15 and 4 nM, respectively, in a...
| Schlagworte: | 3-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-N-[(2,3,5,6,7,8-hexahydro-1-methyl-3-oxo-4-isoquinolinyl)methyl]-2-methyl-5-[6-(4... |
| Anwendung: | EZH2 inhibitor |
| CAS | 1826865-46-6 |
| MW: | 612.8 D |
ab 111,00 €
