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PF-06260933
Artikelnummer: TGM-T4221-100mg
Description: PF-06260933 is a highly selective small-molecule MAP4K4 inhibitor with IC50s of 3.7 and 160 nM for kinase and cell, respectively. Target: MAPK. Smiles: Nc1ccc(cn1)-c1cnc(N)c(c1)-c1ccc(Cl)cc1. References: Ammirati M, et al. Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based...
| Schlagworte: | PF6260933, PF-6260933, PF 6260933 |
| Anwendung: | MAP4K4 inhibitor |
| CAS | 1811510-56-1 |
| MW: | 296.75 D |
ab 42,00 €
PF-6260933
Artikelnummer: Cay29220-10
PF-6260933 is an inhibitor of mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4, IC50 = 3.7 nM). It is selective for MAP4K4 over a panel of 41 kinases at 1 µM but also inhibits TRAF2- and NCK-interacting kinase (TNIK) and misshapen-like kinase 1 (MINK1, IC50s = 15 and 8 nM, respectively). PF-6260933...
| Schlagworte: | PF-06260933, 5-(4-chlorophenyl)-3,3'-bipyridine]-6,6'-diamine |
| Anwendung: | MAP4K4 inhibitor |
| CAS | 1811510-56-1 |
| MW: | 296.8 D |
ab 153,00 €
