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EN6
Artikelnummer: TGM-T11191-100mg
Description: EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative agent in frontotemporal dementia, in a lysosome-dependent manner. EN6 is a...
| CAS | 1808714-73-9 |
| MW: | 368.34 D |
ab 40,00 €
EN6
Artikelnummer: Cay28715-5
EN6 is an activator of autophagy. It inhibits mammalian target of rapamycin complex 1 (mTORC1) signaling by binding covalently to cysteine 277 of the ATP6V1A catalytic subunit of the lysosomal vacuolar ATPase (v-ATPase) and impairing v-ATPase coupling with Rag GTPases. It is selective for inhibition of mTORC1 over...
| Schlagworte: | N-[4-fluoro-3-[(1-oxo-2-propen-1-yl)amino]phenyl]-1-(2-fluorophenyl)-1H-pyrazole-4-carboxamide |
| Anwendung: | Autophagy activator, mTORC1 inhibitor |
| CAS | 1808714-73-9 |
| MW: | 368.3 D |
ab 110,00 €
