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CPI-360
Artikelnummer: TGM-T6810-100mg
Description: CPI-360 is a small molecule EZH2 inhibitor (IC50: 0.002 µM, EC50: 0.080 µM) that shows antitumor activity in an EZH200-dependent tumor xenograft model. Target: Histone Methyltransferase, Apoptosis. Smiles: [C@H](C)(N1C=2C(C(C(NCC3=C(OC)C=C(C)NC3=O)=O)=C1C)=CC=CC2)C4CCOCC4. References: Vatolin S, et al....
| Schlagworte: | CPI360, Synonym 2, Synonym 2, CPI 360 |
| Anwendung: | Selective EZH2 inhibitor |
| CAS | 1802175-06-9 |
| MW: | 437.53 D |
ab 76,00 €
CPI-360
Artikelnummer: Cay19125-1
CPI-360 is a selective EZH2 inhibitor with IC50 values of 0.5 and 2.5 nM for wild-type EZH2 and Y641N mutant EZH2, respectively. It decreases cellular levels of H3K27me3 and H3K27me2 (EC50s = 56 and 65 nM, respectively), triggering cell cycle arrest and ultimately resulting in apoptosis in a large panel of...
| Schlagworte: | N-[(1,2-dihydro-4-methoxy-6-methyl-2-oxo-3-pyridinyl)methyl]-2-methyl-1-[(1R)-1-(tetrahydro-2H-pyran-4-yl)ethyl]-1H-indole... |
| Anwendung: | Selective EZH2 inhibitor |
| CAS | 1802175-06-9 |
| MW: | 437.5 D |
ab 52,00 €
