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TNO155
Artikelnummer: TGM-T13176-100mg
Description: TNO155 is a protein tyrosine phosphatase (PTP) non-receptor type 11 (SHP2, src homology region 2 domain phosphatase, PTPN11) inhibitor(IC50 : 0.011 µM),with potential antineoplastic activity. Target: Phosphatase. Smiles: C[C@@H]1OCC2(CCN(CC2)c2cnc(Sc3ccnc(N)c3Cl)c(N)n2)[C@@H]1N. References: TNO155: SHP2...
| Schlagworte: | Batoprotafib |
| Anwendung: | SHP-2 inhibitor |
| CAS | 1801765-04-7 |
| MW: | 421.95 D |
ab 91,00 €
TNO155
Artikelnummer: Cay32525-5
TNO155 is an orally bioavailable allosteric inhibitor of Src homology region 2 domain-containing phosphatase 2 (SHP-2, IC50 = 0.011 µM). It is selective for SHP-2 over a panel of 52 kinases and phosphatases (IC50s = >10 µM for all). TNO155 decreases phosphorylation of ERK in, and inhibits proliferation of, KYSE-520...
| Schlagworte: | (3S,4S)-8-[6-amino-5-[(2-amino-3-chloro-4-pyridinyl)thio]-2-pyrazinyl]-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-amine |
| Anwendung: | SHP-2 inhibitor |
| CAS | 1801765-04-7 |
| MW: | 421.9 D |
ab 35,00 €
