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ASTX660
Artikelnummer: TGM-TQ0029-100mg
Description: ASTX660 is an orally bioavailable dual antagonist of cIAP (cellular inhibitor of apoptosis protein) and XIAP (X-linked inhibitor of apoptosis protein). Target: IAP. Smiles: C[C@@H]1CN(CC(=O)N2CC(C)(C)c3nc(CO)c(Cc4ccc(F)cc4)cc23)[C@@H](CN2CCOC[C@H]2C)CN1. References: Tomoko Smyth, et al. Abstract 1287:...
| Anwendung: | IAP protein-peptide interaction non-peptidomimetic inhibitor |
| CAS | 1799328-86-1 |
| MW: | 539.68 D |
ab 75,00 €
ASTX660
Artikelnummer: LKT-A744789.1
ASTX660 is an inhibitor of apoptosis proteins found to target BIR3 domain of cIAP1/2 and XIAP through a TNFalpha dependent mechanism in melanoma, breast cancer, and lymphoma cell studies. In a breast cancer xenograft model ASTX660 inhibited tumor growth while displaying no significant adverse effects. Treatment of...
| Schlagworte: | ASTX660, ASTX-660, ASTX 660, Ethanone,... |
| Anwendung: | cIAP / XIAP dual antagonist |
| CAS | 1799328-86-1 |
| MW: | 539.7 D |
ab 346,00 €
ASTX660
Artikelnummer: Cay36619-1
ASTX660 is an inhibitor of inhibitor of apoptosis (IAP) protein-peptide interactions. It inhibits the protein-peptide interaction between the IAP1 and XIAP BIR3 domains with a Smac-derived peptide in cell-free assays (IC50s = 50 = 2.8 nM) and induces displacement of Smac from XIAP in A375 melanoma cells. It induces...
| Schlagworte: | Tolinapant,... |
| Anwendung: | IAP protein-peptide interaction non-peptidomimetic inhibitor |
| CAS | 1799328-86-1 |
| MW: | 539.7 D |
ab 60,00 €
