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LY2365109 hydrochloride
Artikelnummer: TGM-T11908-100mg
Description: LY2365109 hydrochloride is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8 nM for glycine uptake in cells over-expressing [hGlyT1a]. Target: GlyT. Smiles: Cl.CN(CCOc1ccc(cc1C(C)(C)C)-c1ccc2OCOc2c1)CC(O)=O. References: Perry KW et al. Neurochemical and behavioral profiling of the selective...
| Anwendung: | GlyT1a inhibitor |
| CAS | 1779796-27-8 |
| MW: | 421.91 D |
ab 34,00 €
LY2365109 (hydrochloride)
Artikelnummer: Cay37427-10
LY2365109 is an inhibitor of glycine transporter 1a (GlyT1a, IC50 = 15.8 nM in BE2-C cells expressing the human transporter). It is selective for GlyT1a over GlyT2 (IC50 = >30 µM in RD cells expressing the human transporter). LY2365109 (10 mg/kg) induces locomotor hyperactivity, impaired gait, compulsive walking,...
| Schlagworte: | N-[2-[4-(1,3-benzodioxol-5-yl)-2-(1,1-dimethylethyl)phenoxy]ethyl]-N-methyl-glycine, monohydrochloride |
| Anwendung: | GlyT1a inhibitor |
| CAS | 1779796-27-8 |
| MW: | 421.9 D |
ab 135,00 €
