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TAS-103 dihydrochloride
Artikelnummer: TGM-T7309-100mg
Description: TAS-103 dihydrochloride (BMS-247615 dihydrochloride) is a novel anticancer agent targeting both topoisomerase (Topo) I and Topo II. Target: Topoisomerase. Smiles: Cl.Cl.CN(C)CCNc1nc2cc(O)ccc2c2-c3ccccc3C(=O)c12. References: Aoyagi Y , Kobunai T , Utsugi T , et al. In vitro Antitumor Activity of TAS-103,...
| Schlagworte: | TAS-103 (dihydrochloride), BMS-247615 dihydrochloride |
| Anwendung: | DNA topoisomerase I & II inhibitor |
| CAS | 174634-09-4 |
| MW: | 406.31 D |
ab 40,00 €
TAS 103 (hydrochloride)
Artikelnummer: Cay29869-10
TAS 103 is an inhibitor of DNA topoisomerase I and II (IC50s = 2 and 6.5 µM, respectively). It stabilizes topoisomerase I-DNA and topoisomerase II-DNA cleavable complexes in KB cells when used at a concentration of 3 µM. It is cytotoxic to P388 and KB cells (IC50s = 1.1 and 9.6 nM, respectively). TAS 103 (15, 26,...
| Schlagworte: | 6-[[2-(dimethylamino)ethyl]amino]-3-hydroxy-7H-indeno[2,1-c]quinolin-7-one, dihydrochloride |
| Anwendung: | DNA topoisomerase I & II inhibitor |
| CAS | 174634-09-4 |
| MW: | 406.3 D |
ab 166,00 €
