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HMN-214
Artikelnummer: Cay26210-1
HMN-214 is an orally bioavailable prodrug form of HMN-176, an indirect inhibitor of polo-like kinase (PLK) activity that inhibits proliferation of a variety of cancer cells. HMN-214 decreases the expression of multidrug resistance gene 1 (MDR1) in AB-A.1 cells and in tumors isolated from mice bearing...
| Schlagworte: | IVX-214, N-[(4-methoxyphenyl)sulfonyl]-N-[2-[(1E)-2-(1-oxido-4-pyridinyl)ethenyl]phenyl]-acetamide |
| Anwendung: | Indirect PLK inhibitor |
| CAS | 173529-46-9 |
| MW: | 424.5 D |
ab 44,00 €
HMN-214
Artikelnummer: TGM-T2438-100mg
Description: HMN-214 (IVX-214) is a potent PLK1 inhibitor with an average IC50 of 0.12 µM. Target: PLK. Smiles: N(S(=O)(=O)C1=CC=C(OC)C=C1)(C(C)=O)C2=C(/C=C/C=3C=CN(=O)=CC3)C=CC=C2. References: Takagi M, et al. Invest New Drugs, 2003, 21(4), 387-399.
| Schlagworte: | IVX-214, HMN214 |
| CAS | 173529-46-9 |
| MW: | 424.47 D |
ab 34,00 €
