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PP2
Artikelnummer: TGM-T6266-100mg
Description: PP2 (AG 1879,AGL 1879) is a effective inhibitor of Lck/Fyn (IC50:4/5 nM) , ~100-fold less potent to EGFR, inactive for ZAP-70, PKA and JAK2. Target: EGFR, Tyrosine Kinases, Src, JAK. Smiles: NC1=C2C(=NN(C(C)(C)C)C2=NC=N1)C3=CC=C(Cl)C=C3. References: Hanke JH, et al. J Biol Chem, 1996, 271(2), 695-701.
| Schlagworte: | AG 1879,AGL 1879, AGL 1879 |
| Anwendung: | Tyrosine kinase inhibitor |
| CAS | 172889-27-9 |
| MW: | 301.77 D |
ab 39,00 €
PP2
Artikelnummer: Cay13198-1
The Src family of non-receptor tyrosine kinases regulate cell adhesion, growth, and differentiation through activation of multiple intracellular signaling pathways. Normally inactive, Src kinases are transiently activated during mitosis and constitutively activated by abnormal mutations. PP2 is a potent, reversible,...
| Schlagworte: | AGL 1879, 3-(4-chlorophenyl)-1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| Anwendung: | Tyrosine kinase inhibitor |
| CAS | 172889-27-9 |
| MW: | 301.8 D |
ab 43,00 €
PP2
Artikelnummer: AG-CR1-3563-M001
Highly potent and selective Scr family tyrosine kinase inhibitor. Shows anti-Ras cancer potential by blocking Ras-induced activation of PAK1. Antitumor compound. RIP2 inhibitor. Blocks TGF-beta-mediated cellular responses.
| Schlagworte: | 4-Amino-5-(4-chlorophenyl)-7-(tert.butyl)pyrazolo-(3,4-d)pyrimidine, AG 1879 |
| Anwendung: | Tyrosine kinase inhibitor |
| CAS | 172889-27-9 |
| MW: | 301,8 D |
ab 44,00 €
