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CCT251545
Artikelnummer: TGM-T14907-100mg
Description: CCT251545 is an potent and oral-bioavailable WNT signaling inhibitor(IC50 of 5 nM in 7dF3 cells). Target: Wnt/beta-catenin. Smiles: Cn1cc(cn1)-c1ccc(cc1)-c1cncc(Cl)c1N1CCC2(CCNC2=O)CC1. References: Dale T, et al. A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease. Nat...
| Anwendung: | CDK8 / CDK19 inhibitor |
| CAS | 1661839-45-7 |
| MW: | 421.92 D |
ab 37,00 €
CCT251545
Artikelnummer: Cay18761-5
CCT251545 is an orally bioavailable inhibitor of Wnt signaling (IC50 = 5 nM). It is a potent and selective inhibitor of the human mediator complex-associated protein kinases Cdk8 and Cdk19. Through its effects on Cdk8 and Cdk19, CCT251545 alters Wnt pathway-regulated gene expression. It reduces tumor growth in COLO...
| Schlagworte: | 8-[3-chloro-5-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]-4-pyridinyl]-2,8-diazaspiro[4.5]decan-1-one |
| Anwendung: | CDK8 / CDK19 inhibitor |
| CAS | 1661839-45-7 |
| MW: | 421.9 D |
ab 67,00 €
