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ONO-7475
Artikelnummer: TGM-T8327-100mg
Description: ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase. Target: Trk receptor, TAM Receptor. Smiles: COc1cc2nccc(Oc3ccc(NC(=O)c4cc5C(=O)CCCc5n(-c5ccccc5)c4=O)nc3)c2cc1OC. References: Ruvolo PP, et al. Anexelekto/MER tyrosine kinase inhibitor ONO-7475 arrests growth and...
| Anwendung: | Axl / Mer inhibitor |
| CAS | 1646839-59-9 |
| MW: | 562.57 D |
ab 57,00 €
ONO-7475
Artikelnummer: Cay33258-1
ONO-7475 is an inhibitor of the TAM family kinases Axl and Mer (IC50s = 0.7 and 1 nM, respectively). It is selective for Axl and Mer over FLT3 (IC50 = 147 nM). ONO-7475 (10 nM) reduces viability of, and induces apoptosis in, MOLM-13 and MV4-11 leukemia cells. In vivo, ONO-7475 (6 mg/kg) reduces leukemic burden and...
| Schlagworte: | N-[5-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-pyridinyl]-1,2,5,6,7,8-hexahydro-2,5-dioxo-1-phenyl-3-quinolinecarboxamide |
| Anwendung: | Axl / Mer inhibitor |
| CAS | 1646839-59-9 |
| MW: | 562.6 D |
ab 94,00 €
