Zu "1644443-47-9" wurden 2 Artikel gefunden!
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Autophinib
Artikelnummer: TGM-T4219-100mg
Description: Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay and rapamycin induced autophagy assay. Target: Autophagy, PI3K. Smiles: Cc1cc(Nc2cc(Cl)nc(Oc3ccc(cc3)[N+]([O-])=O)n2)n[nH]1. References: Robke L, et al....
| Anwendung: | VPS34 inhibitor |
| CAS | 1644443-47-9 |
| MW: | 346.73 D |
ab 33,00 €
Autophinib
Artikelnummer: Cay27320-1
Autophinib is an ATP-competitive inhibitor of the PI3K VPS34 (IC50 = 19 nM). It inhibits autophagy induced by the mTOR inhibitor rapamycin (Cay-13346) or by amino acid starvation (IC50s = 40 and 90 nM, respectively) in MCF-7 cells. Autophinib also induces apoptosis in amino acid-starved MCF-7 cells with an EC50...
| Schlagworte: | 6-chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-4-pyrimidinamine |
| Anwendung: | VPS34 inhibitor |
| CAS | 1644443-47-9 |
| MW: | 346.7 D |
ab 35,00 €
