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FIIN-2
Artikelnummer: TGM-T6836-10mg
Description: FIIN-2, an irreversible, pan-FGFR inhibitor, inhibits FGFR1/2/3/4 with IC50 of 3.09 nM, 4.3 nM, 27 nM and 45.3 nM, respectively. Target: FGFR. Smiles: COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc2N(Cc2ccc(NC(=O)C=C)cc2)C1=O. References: Tan L, et al. Proc Natl Acad Sci U S A. 2014, 111(45),...
| Anwendung: | FGFR inhibitor |
| CAS | 1633044-56-0 |
| MW: | 634.73 D |
ab 35,00 €
FIIN-2
Artikelnummer: Cay19837-1
FIIN-2 is an irreversible FGFR inhibitor with IC50 values of 3.09, 4.3, 27, and 45.3 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively. It has been shown to inhibit cell proliferation of transformed Ba/F3 cell lines and demonstrates antiproliferative activity in cells dependent upon the gatekeeper mutants of FGFR1...
| Schlagworte: | N-[4-[[3-(3,5-dimethoxyphenyl)-3,4-dihydro-7-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-oxopyrimido[4,5-d]pyrimidin-1(2H)... |
| Anwendung: | FGFR inhibitor |
| CAS | 1633044-56-0 |
| MW: | 634.7 D |
ab 60,00 €
