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AG-636
Artikelnummer: TGM-T9121-100mg
Description: AG-636 is a potent, reversible, and selective DHODH inhibitor with an IC50 of 17 nM and is orally active. It demonstrates strong anticancer effects. Target: DNA/RNA Synthesis, Dehydrogenase. Smiles: Cc1ccccc1-c1ccc(cc1)-c1cc(C(O)=O)c2n(C)nnc2c1. References: Gabrielle McDonald, et al. Selective...
| Anwendung: | DHODH inhibitor |
| CAS | 1623416-31-8 |
| MW: | 343.38 D |
ab 67,00 €
AG-636
Artikelnummer: Cay36122-1
AG-636 is a dihydroorotate dehydrogenase (DHODH) inhibitor (IC50 = 17 nM). It increases levels of ureidosuccinic acid (Cay-34126) and DHO, pyrimidine biosynthesis metabolites upstream of DHODH, in a panel of six cell lines when used at a concentration of 1 µM. AG-636 (100 mg/kg) induces complete tumor stasis in an...
| Schlagworte: | 1-methyl-5-(2'-methyl[1,1'-biphenyl]-4-yl)-1H-benzotriazole-7-carboxylic acid |
| Anwendung: | DHODH inhibitor |
| CAS | 1623416-31-8 |
| MW: | 343.4 D |
ab 76,00 €
