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TIC10
Artikelnummer: TGM-T7001-100mg
Description: TIC10 (ONC-201) inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. Phase 1/2. Target: Apoptosis, TNF. Smiles: Cc1ccccc1CN1C2=NCCN2C2=C(CN(Cc3ccccc3)CC2)C1=O. References:...
| Schlagworte: | ONC-201 |
| Anwendung: | Targets dopamine receptor D2 (DRD2) |
| CAS | 1616632-77-9 |
| MW: | 386.49 D |
ab 49,00 €
TIC10
Artikelnummer: Cay16109-5
TIC10 induces the expression of TNF-related apoptosis-inducing ligand (TRAIL) at 1-5 µM in a p53-independent manner. It is orally active, stable, and crosses the blood-brain barrier. The induction of TRAIL results from dual inhibition of Akt and ERK1/2 combined with nuclear translocation of the transcription factor...
| Schlagworte: | ONC201, 2,4,6,7,8,9-hexahydro-4-[(2-methylphenyl)methyl]-7-(phenylmethyl)-imidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one |
| Anwendung: | TRAIL expression inducer |
| CAS | 1616632-77-9 |
| MW: | 386.5 D |
ab 44,00 €
