Zu "1616392-22-3" wurden 2 Artikel gefunden!
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GSK3326595
Artikelnummer: TGM-T5745-100mg
Description: GSK3326595 (EPZ015938) is an inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50:6.2 nM.). Target: Histone Methyltransferase. Smiles: CC(=O)N1CCC(CC1)Nc1cc(ncn1)C(=O)NC[C@@H](O)CN1CCc2ccccc2C1. References: Gerhart S V , Kellner W A , Christine T , et al. Activation of the p53-MDM4 regulatory...
| Schlagworte: | EPZ015938 |
| Anwendung: | PRMT5 inhibitor |
| CAS | 1616392-22-3 |
| MW: | 452.55 D |
ab 40,00 €
GSK3326595
Artikelnummer: Cay27305-1
GSK3326595 is an inhibitor of protein arginine methyltransferase 5 (PRMT5). It inhibits methylation of peptides derived from the PRMT5 substrates histone H4 and H2A, SmD3, FUBP1, and HNRNPH1 by the PRMT5/MEP50 complex with IC50 values ranging from 5.9 to 19.7 nM and is more than 4,000-fold selective for PRMT5/MEP50...
| Schlagworte: | 6-[(1-acetyl-4-piperidinyl)amino]-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-4-pyrimidinecarboxamide |
| Anwendung: | PRMT5 inhibitor |
| CAS | 1616392-22-3 |
| MW: | 452.6 D |
ab 44,00 €
