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AZ191
Artikelnummer: AG-CR1-3657-M001
White to off-white solid. Soluble in DMSO (5mg/ml), ethanol (2mg/ml) or DMF (2mg/ml). Cell permeable azaindole that inhibits the serine/threonine kinase activity of DYRK1B (IC50=17nM) with 5-fold and 110-fold selectivity against the related family members DYRK1A and DYRK2, respectively, Used as a probe to elucidate...
| Schlagworte: | N-[2-Methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine |
| Anwendung: | Cell permeable DYRK1B inhibitor |
| CAS | 1594092-37-1 |
| MW: | 429,5 D |
ab 28,00 €
AZ191
Artikelnummer: Cay17693-1
Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B (DYRK1B) belongs to a family of nuclear-localized protein kinases and participates in the regulation of the cell cycle with key roles in proliferation and differentiation. It is upregulated in solid tumors and gain-of-function mutations in the gene...
| Schlagworte: | N-[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine |
| Anwendung: | Cell-permeable DYRK1B serine/threonine kinase activity inhibitor |
| CAS | 1594092-37-1 |
| MW: | 429.5 D |
ab 43,00 €
