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3-Oxo-5beta-cholanoic acid
Artikelnummer: TGM-T13502-10mg
Description: 3-Oxo-5beta-cholanoic acid (Dehydrolithocholic acid) is a bile acid metabolite that inhibits TH17 cell differentiation by directly binding to the transcription factor RORgammat with a Kd of 1.13 µM. Target: ROR. Smiles: C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C....
| Schlagworte: | Dehydrolithocholic acid |
| Anwendung: | Major lithocholic acid metabolite, TGR5 / VDR / FXR agonist |
| CAS | 1553-56-6 |
| MW: | 374.56 D |
ab 41,00 €
Dehydrolithocholic Acid
Artikelnummer: Cay29544-10
Dehydrolithocholic acid is a major metabolite of lithocholic acid (LCA, Cay-20253). It is formed from LCA by the cytochrome P450 (CYP) isoform CYP3A4. Dehydrolithocholic acid is an agonist of G protein-coupled bile acid activated receptor 1 (GP-BAR1/TGR5, EC50 = 0.27 µM), vitamin D receptor (VDR, EC50 = 3 µM), and...
| Schlagworte: | 3-Ketolithocholic Acid, 3-oxo Lithocholic Acid, 3-oxoLCA, (5beta)-3-oxo-cholan-24-oic acid |
| Anwendung: | Major lithocholic acid metabolite, TGR5 / VDR / FXR agonist |
| CAS | 1553-56-6 |
| MW: | 374.6 D |
ab 43,00 €
