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NSC 109555
Artikelnummer: TGM-T33737-10mg
Description: NSC 109555 is a selective, reversible, ATP-competitive Chk2 inhibitor (IC50 = 0.2 µM) that displays no effect on a range of other kinases including Chk1 (IC50 > 10 µM). Inhibits histone H1 phosphorylation (IC50 = 0.24 µM) and attenuates mitochondrial ATP synthesis. Exhibits antiproliferative activity in...
| Schlagworte: | NSC-109555, DDUG dimethanesulfonate, NSC109555, DDUG diMS |
| Anwendung: | Chk2 inhibitor |
| CAS | 15427-93-7 |
| MW: | 600.67 D |
ab 62,00 €
NSC 109555
Artikelnummer: Cay19811-1
NSC 109555 is an ATP-competitive inhibitor of checkpoint kinase 2 (Chk2, IC50 = 200 nM in a cell-free kinase assay). It is selective for Chk2 over Chk1 and 16 kinases in a panel but does inhibit Brk, c-Met, IGFR, and LCK with IC50 values of 210, 6,000, 7,400, and 7,100 nM, respectively. NSC 109555 inhibits Chk2...
| Schlagworte: | DDUG, NCI C04808, 2,2'-[carbonylbis(imino-4,1-phenyleneethylidyne)]bis-hydrazinecarboximidamide, dimethanesulfonate |
| Anwendung: | Chk2 inhibitor |
| CAS | 15427-93-7 |
| MW: | 600.7 D |
ab 35,00 €
