Zu "1536200-31-3" wurden 2 Artikel gefunden!
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GNE-9605
Artikelnummer: TGM-T1770-100mg
Description: GNE-9605 is a highly effective, specifical, and brain-penetrant LRRK2 inhibitor (IC50: 19 nM). Target: LRRK2. Smiles: CNc1nc(Nc2cnn([C@H]3CCN(C[C@@H]3F)C3COC3)c2Cl)ncc1C(F)(F)F. References: Estrada AA , et al. J Med Chem. 2014, 57(3), 921-936.
| Anwendung: | LRRK2 inhibitor |
| CAS | 1536200-31-3 |
| MW: | 449.83 D |
ab 33,00 €
GNE-9605
Artikelnummer: Cay23446-1
GNE-9065 is an orally bioavailable and potent inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 = 18.7 nM). It is selective for LRRK2 over 178 kinases, inhibiting only TAK1-TAB1 >50% at a concentration of 0.1 µM. GNE-9065 (10 and 50 mg/kg) inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice...
| Schlagworte: | rel-N2-[5-chloro-1-[(3R,4R)-3-fluoro-1-(3-oxetanyl)-4-piperidinyl]-1H-pyrazol-4-yl]-N4-methyl-5-(trifluoromethyl)-2,4-pyri... |
| Anwendung: | LRRK2 inhibitor |
| CAS | 1536200-31-3 |
| MW: | 449.8 D |
ab 55,00 €
