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Nolatrexed dihydrochloride
Artikelnummer: TGM-T2627-10mg
Description: Nolatrexed dihydrochloride (Thymitaq) is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine...
| Schlagworte: | Thymitaq, AG 337 |
| Anwendung: | Thymidylate synthase inhibitor |
| CAS | 152946-68-4 |
| MW: | 357.26 D |
ab 41,00 €
Nolatrexed (hydrochloride)
Artikelnummer: Cay29247-10
Nolatrexed is a thymidylate synthase inhibitor (Ki = 11 nM). It inhibits cell growth in a panel of human and murine cancer cell lines (IC50s = 0.39-6.6 µM). Nolatrexed inhibits the growth of L1210 cells, an effect that is decreased by greater than 50-fold by the addition of exogenous thymidine. Nolatrexed (0.7 and...
| Schlagworte: | AG337, 2-amino-6-methyl-5-(4-pyridinylthio)-4(1H)-quinazolinone, dihydrochloride |
| Anwendung: | Thymidylate synthase inhibitor |
| CAS | 152946-68-4 |
| MW: | 357.3 D |
ab 78,00 €
