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SAR405
Artikelnummer: TGM-T12831L-10mg
Description: SAR-405 is a potent and selective PIK3C3/Vps34 inhibitor (IC50:1.2 nM, Kd:1.5 nM) that prevents autophagy and synergizes with MTOR inhibition in tumor cells. SAR405 treatment also inhibits autophagy induced either by starvation or by MTOR (mechanistic target of rapamycin) inhibition. Combining SAR405...
| Anwendung: | PIK3C3 / Vps34 inhibitor |
| CAS | 1523406-39-4 |
| MW: | 443.85 D |
ab 50,00 €
SAR405
Artikelnummer: Cay16979-1
SAR405 is an inhibitor of the phosphoinositide 3-kinase (PI3K) class III isoform Vps34 (IC50 = 1.2 nM). It is without effect (IC50 > 10,000 nM) on other PI3K isoforms and mTOR. SAR405 alters vesicle trafficking and inhibits autophagy by blocking autophagosome formation. SAR405 also synergizes with the mTOR inhibitor...
| Schlagworte: | (8S)-9-[(5-chloro-3-pyridinyl)methyl]-6,7,8,9-tetrahydro-2-[(3R)-3-methyl-4-morpholinyl]-8-(trifluoromethyl)-4H-pyrimido[1... |
| Anwendung: | PIK3C3 / Vps34 inhibitor |
| CAS | 1523406-39-4 |
| MW: | 443.9 D |
ab 63,00 €
