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Nazartinib
Artikelnummer: TGM-T3506-100mg
Description: Nazartinib (EGF816) (EGF816, NVS-816) is a covalent, irreversible, mutant-selective EGFR inhibitor that has nanomolar inhibitory potency against activating mt (L858R, ex19del) and T790M mt, with up to 60-fold selectivity over wild type (wt) EGFR in vitro. Target: EGFR. Smiles:...
| Schlagworte: | EGF816, NVS-816 |
| Anwendung: | Targets epidermal growth factor receptor [EC:2.7.10.1] (EGFR, ERBB1) |
| CAS | 1508250-71-2 |
| MW: | 495.02 D |
ab 32,00 €
Nazartinib
Artikelnummer: Cay22409-1
Nazartinib is an irreversible inhibitor of mutant EGF receptors (EGFRs). It is selective for EGFR mutant cell lines, including H3255 and HCC827 lung adenocarcinoma cells (IC50s = 6.11 and 1.52 nM, respectively) and resistant H1975 non-small cell lung cancer cells (NSCLC, IC50 = 4.18 nM), over cells expressing...
| Schlagworte: | N-[7-chloro-1-[(3R)-1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]hexahydro-1H-azepin-3-yl]-1H-benzimidazol-2-yl]-2-methyl-... |
| Anwendung: | Mutant-selective EGFR inhibitor |
| CAS | 1508250-71-2 |
| MW: | 495 D |
ab 50,00 €
