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VX-984
Artikelnummer: Cay42072-1
VX-984 is an inhibitor of DNA protein kinase (DNA-PK). It inhibits radiation-induced increases in phosphorylated DNA-PK levels in U251 and NSC11 glioblastoma cells when used at concentrations of 250 or 500 nM. VX-984 (1 µM) induces mutagenic NHEJ and homologous recombination DNA repair pathways in a reporter assay...
| Schlagworte: | M-9831, N-methyl-8-[(1S)-1-methyl-2-[(2'-methyl[4,5'-bipyrimidin]-6-yl-4',6'-d2)amino]ethyl]-4-quinolinecarboxamide |
| Anwendung: | DNA-PK inhibitor |
| CAS | 1476074-39-1 |
| MW: | 415.5 D |
ab 108,00 €
VX-984
Artikelnummer: TGM-T11067-100mg
Description: VX-984 (M9831) is an oral, selective DNA-PK inhibitor that can cross the blood-brain barrier. VX-984 inhibited the conjugation of non-homologous terminal NHEJ and acted on DSBs to break DNA double strand. VX-984 is commonly seen in glioblastoma (GBM) and non-small cell lung cancer (NSC-LC) studies....
| Schlagworte: | M9831 |
| CAS | 1476074-39-1 |
| MW: | 415.49 D |
ab 105,00 €
