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Flavopiridol
Artikelnummer: TGM-T6837-10mg
Description: Flavopiridol (Alvocidib) (Alvocidib) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1, 2, 4, 6 versus CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Phase 1/2. Target: CDK, HIV Protease, Apoptosis,...
| Schlagworte: | HMR-1275, L868275, Alvocidib, NSC 649890 HCl |
| Anwendung: | Targets cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23] (CDK1, CDC2) |
| CAS | 146426-40-6 |
| MW: | 401.84 D |
ab 34,00 €
Flavopiridol
Artikelnummer: Cay26024-5
Flavopiridol is an orally bioavailable inhibitor of cyclin dependent kinases (IC50s = ~100, ~100, ~100, and 300 nM for Cdk1, Cdk2, Cdk4, and Cdk7, respectively). It also inhibits TEFb, a complex composed of Cdk9 and cyclin T1, with a Ki value of 3 nM. Flavopiridol inhibits transcription of a CMV promoter in HeLa...
| Schlagworte: | Alvocidib, HL 275, HMR 1275, L-868,275,... |
| Anwendung: | Cyclin dependent kinase inhibitor |
| CAS | 146426-40-6 |
| MW: | 401.8 D |
ab 78,00 €
