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G-749
Artikelnummer: TGM-T2620-100mg
Description: G-749, a new-type FLT3 inhibitor, exhibits effective and sustained inhibition of the FLT3 wild type and mutants. Target: TAM Receptor, c-RET, Apoptosis, FLT, Aurora Kinase. Smiles: CN1CCC(CC1)Nc1nc(Nc2ccc(Oc3ccccc3)cc2)c2c(n1)c(Br)c[nH]c2=O. References: Lee HK, et al. Blood. 2014, 123(14), 2209-2219.
| Schlagworte: | Denfivontinib, G749 |
| Anwendung: | FLT3 inhibitor |
| CAS | 1457983-28-6 |
| MW: | 521.41 D |
ab 42,00 €
G-749
Artikelnummer: Cay22139-1
G-749 is an inhibitor of Fms-like tyrosine receptor kinase 3 (FLT3) with IC50 values ranging from 2.1 to 38.1 nM for wild-type and mutant (constitutively active) FLT3s in Ba/F3 cells expressing recombinant receptors. It also inhibits growth of human leukemia cell lines that express FLT3-ITD mutant kinase (IC50s =...
| Schlagworte: | 8-bromo-2-[(1-methyl-4-piperidinyl)amino]-4-[(4-phenoxyphenyl)amino]-pyrido[4,3-d]pyrimidin-5(6H)-one |
| Anwendung: | FLT3 inhibitor |
| CAS | 1457983-28-6 |
| MW: | 521.4 D |
ab 83,00 €
