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SAR-20347
Artikelnummer: TGM-T4210-100mg
Description: SAR-20347 is an inhibitor of TYK2 and JAK1/2/3, with IC50 values of 0.6 nM, 23 nM, 26 nM, and 41 nM, respectively. Target: Tyrosine Kinases, JAK. Smiles: NC(=O)c1nc(oc1Nc1ccc(cc1)C(=O)N1CCOCC1)-c1c(F)cccc1Cl. References: Works MG, et al. Inhibition of TYK2 and JAK1 ameliorates imiquimod-induced...
| Schlagworte: | SAR20347 |
| Anwendung: | JAK family kinase inhibitor |
| CAS | 1450881-55-6 |
| MW: | 444.84 D |
ab 31,00 €
SAR20347
Artikelnummer: Cay29248-1
SAR20347 is an inhibitor of the JAK family kinases TYK2 and JAK1-3 (IC50s = 0.6, 23, 26, and 41 nM, respectively, in cell-free assays). It inhibits IL-12-induced TYK2-dependent phosphorylation of STAT4 in NK-92 cells (IC50 = 126 nM) and IL-6-induced JAK1-dependent STAT3 signaling in TF-1 cells (IC50 = 345 nM)....
| Schlagworte: | 2-(2-chloro-6-fluorophenyl)-5-[[4-(4-morpholinylcarbonyl)phenyl]amino]-4-oxazolecarboxamide |
| Anwendung: | JAK family kinase inhibitor |
| CAS | 1450881-55-6 |
| MW: | 444.8 D |
ab 49,00 €
