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Senexin B
Artikelnummer: TGM-T8430-100mg
Description: Senexin B is a potent and selective inhibitor of CDK8/19(CDK8 and CDK19 with Kds of 140 nM and 80 nM). Target: CDK. Smiles: CN1CCN(CC1)C(=O)c1ccc2cc(CCNc3ncnc4ccc(cc34)C#N)ccc2c1. References: Porter D, et al. Abstract PR08: Targeting tumor microenvironment with selective small-molecule inhibitors of...
| Anwendung: | Cdk8/Cdk19 inhibitor |
| CAS | 1449228-40-3 |
| MW: | 450.53 D |
ab 98,00 €
Senexin B
Artikelnummer: Cay28459-1
Senexin B is an inhibitor of Cdk8 and Cdk19. It inhibits Cdk8 with IC50 values ranging from 24 to 50 nM, depending on the assay used. It selectively inhibits Cdk19 and Cdk8 by 98.6 and 97.8%, respectively, in a panel of greater than 450 kinases at 2 µM but does inhibit MAP4K2 and YSK4 by 69 and 59%, respectively....
| Schlagworte: | SNX2-1-165, 4-[[2-[6-[(4-methyl-1-piperazinyl)carbonyl]-2-naphthalenyl]ethyl]amino]-6-quinazolinecarbonitrile |
| Anwendung: | Cdk8/Cdk19 inhibitor |
| CAS | 1449228-40-3 |
| MW: | 450.5 D |
ab 44,00 €
