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Pamiparib
Artikelnummer: TGM-T5058-10mg
Description: Pamiparib (BGB-290) is an orally active, potent, highly selective PARP inhibitor with IC50 values of 0.9 nM for PARP1 and 0.5 nM for PARP2. It exhibits strong PARP trapping, has the capability to penetrate the brain, and is used for researching various cancers, including solid tumors. Target: PARP....
| Schlagworte: | BGB-290 |
| Anwendung: | Targets poly [ADP-ribose] polymerase 1 [EC:2.4.2.30] (PARP1) |
| CAS | 1446261-44-4 |
| MW: | 298.31 D |
ab 31,00 €
Pamiparib
Artikelnummer: Cay33182-10
Pamiparib is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1) and PARP2 (IC50s = 1.3 and 0.92 nM, respectively). It is selective for PARP1 and PARP2 over PARP3 (IC50 = 0.068 µM) and other PARP isoforms (IC50s = 2.4->100 µM), as well as over tankyrase 1 (TNKS1) and TNKS2 (IC50s = 0.23 and 0.14 µM, respectively)....
| Schlagworte: | BGB-290, (10aR)-2-fluoro-5,8,9,10,10a,11-hexahydro-10a-methyl-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(7H)-one |
| Anwendung: | Antineoplastic, PARP1 / PARP2 inhibitor |
| CAS | 1446261-44-4 |
| MW: | 298.3 D |
ab 133,00 €
