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JAK3-IN-6
Artikelnummer: TGM-T5492-100mg
Description: JAK3-IN-6 is irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC50 of 0.15 nM. Target: JAK. Smiles: CCOC(=O)c1c[nH]c2ncnc(-c3cccc(NC(=O)C(C)=C)c3)c12. References: Elwood F, et al. Evaluation of JAK3 Biology in Autoimmune Disease Using a Highly Selective, Irreversible JAK3 Inhibitor. J...
| Anwendung: | JAK3 inhibitor |
| CAS | 1443235-95-7 |
| MW: | 350.37 D |
ab 34,00 €
JAK3-IN-2
Artikelnummer: Cay37344-100
JAK3-IN-2 is an inhibitor of JAK3 (Ki = 0.07 nM). It is selective for JAK3 over JAK1 and JAK2 (Kis = 320 and 740 nM, respectively). JAK3-IN-2 inhibits IL-2-induced STAT5 gene expression in a reporter assay (IC50 = 70 nM). In vivo, JAK3-IN-2 (100, 300, and 600 mg/kg) reduces paw swelling and ankle bone loss in a rat...
| Schlagworte: | Janus-Associated Kinase 3 Inhibitor 2, JAK3-Inhibitor 2,... |
| Anwendung: | JAK3 inhibitor |
| CAS | 1443235-95-7 |
| MW: | 350.4 D |
ab 347,00 €
