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Ripretinib
Artikelnummer: TGM-T8482-100mg
Description: Ripretinib (DCC-2618) is an orally bioavailable inhibitor of (KIT) and (PDGFRA). Target: PDGFR, FLT, Apoptosis, VEGFR, c-Kit. Smiles: CCn1c2cc(NC)ncc2cc(-c2cc(NC(=O)Nc3ccccc3)c(F)cc2Br)c1=O. References: Schneeweiss M, et al. The KIT and PDGFRA switch-control inhibitor DCC-2618 blocks growth and...
| Schlagworte: | DCC-2618 |
| Anwendung: | Targets proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1] (KIT, SCFR, CD117) |
| CAS | 1442472-39-0 |
| MW: | 510.36 D |
ab 67,00 €
Ripretinib
Artikelnummer: Cay33782-10
Ripretinib is an inhibitor of KIT and PDGFRalpha (IC50s = 3 and 3.6 nM, respectively). It is selective for KIT and PDGFRalpha over a panel of 300 kinases (IC50s = >100 nM) but does inhibit DDR2, VEGFR2, PDGFRbeta, and Tie2 (IC50s = V654A, KITT670I, KITD816H, KITD816V, and PDGFRalphaD842V (IC50s = 11, 9.2, 18, 25,...
| Schlagworte: | DCC-2618, N-[4-bromo-5-[1-ethyl-1,2-dihydro-7-(methylamino)-2-oxo-1,6-naphthyridin-3-yl]-2-fluorophenyl]-N'-phenyl-urea |
| Anwendung: | KIT / PDGFRalpha inhibitor |
| CAS | 1442472-39-0 |
| MW: | 510.4 D |
ab 109,00 €
