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AKI603
Artikelnummer: TGM-T64338-100mg
Description: AKI603 is a novel small molecule inhibitor of Aurora kinase A (AurA)(IC50 = 12.3 nM). AKI603 is developed to overcome resistance mediated by BCR-ABL-T315I mutation. AKI603 exhibits strong anti-proliferative activity in leukemic cells[1][2]. Target: Aurora Kinase. Smiles:...
| Schlagworte: | AKI-603, AKI 603 |
| Anwendung: | Aurora A kinase inhibitor |
| CAS | 1432515-73-5 |
| MW: | 409.45 D |
ab 98,00 €
AKI-603
Artikelnummer: Cay40840-1
AKI-603 is an inhibitor of Aurora A kinase (IC50 = 12 nM). It reduces the proliferation of HL-60 promyeoloblast leukemia cells, K562 chronic myeloid leukemia (CML) cells, U937 lymphoma monocytes, MOLT-4 T cell lymphoblasts, and MCF-7 and MDA-MD-231 breast cancer cells (IC50s = 69, 137, 43, 18, 424, and 84 nM,...
| Schlagworte: | 6-(4-methyl-1-piperazinyl)-N4-(5-methyl-1H-pyrazol-3-yl)-N2-(4-nitrophenyl)-2,4-pyrimidinediamine |
| Anwendung: | Aurora A kinase inhibitor |
| CAS | 1432515-73-5 |
| MW: | 409.5 D |
ab 141,00 €
