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Lats-IN-1
Artikelnummer: TGM-T9053-100mg
Description: Lats-IN-1 is a potent and ATP-competitive Lats1 and Lats2 kinases inhibitor. It promotes Yap-dependent proliferation in postmitotic mammalian tissues. Target: YAP, Others. Smiles: O=C(\N=c1/sccn1Cc1ccccc1)c1c[nH]c2ncccc12. References: Nathaniel Kastan, et al. Small-molecule inhibition of Lats kinases...
| Anwendung: | LATS1 / LATS2 inhibitor |
| CAS | 1424635-83-5 |
| MW: | 334.39 D |
ab 67,00 €
LATS-IN-1
Artikelnummer: Cay36623-5
LATS-IN-1 is an inhibitor of large tumor suppressor kinase 1 (LATS1) and LATS2 (IC50 = 2 nM for both), key regulators of Hippo regenerative signaling. It inhibits phosphorylation of YES1-associated transcriptional regulator (YAP1) in serum-starved HEK293A cells (EC50 = 510 nM). LATS-IN-1 (10 µM) increases the...
| Schlagworte: | LATS Inhibitor 1, TRULI, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]-1H-pyrrolo[2,3-b]pyridine-3-carboxamide |
| Anwendung: | LATS1 / LATS2 inhibitor |
| CAS | 1424635-83-5 |
| MW: | 334.4 D |
ab 40,00 €
