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NVP-TNKS656
Artikelnummer: TGM-T3261-100mg
Description: NVP-TNKS656 (TNKS656) is a highly potent, selective, and orally active TNKS2 inhibitor. Target: PARP, Apoptosis, Wnt/beta-catenin. Smiles: COc1ccc(cc1)C(=O)C1CCN(CC(=O)N(CC2CC2)Cc2nc3CCOCc3c(=O)[nH]2)CC1. References: Shultz MD, et al. J Med Chem. 2013, 56(16), 6495-6511.
| Schlagworte: | TNKS656 |
| Anwendung: | Tankyrase inhibitor |
| CAS | 1419949-20-4 |
| MW: | 494.58 D |
ab 40,00 €
NVP-TNKS656
Artikelnummer: Cay19930-5
NVP-TNKS656 is an orally bioavailable inhibitor of tankyrase 2 (TNKS2, IC50 = 6 nM). It is selective for TNKS2 over poly(ADP-ribose) polymerase (PARP) 1 and 2 (IC50s = >19 and 32 nM, respectively). NVP-TNKS656 inhibits Wnt ligand-induced signaling with an IC50 value of 3.5 nM in an HEK293 cell reporter assay. In...
| Schlagworte: | N-(cyclopropylmethyl)-4-(4-methoxybenzoyl)-N-[(3,5,7,8-tetrahydro-4-oxo-4H-pyrano[4,3-d]pyrimidin-2-yl)methyl]-1-piperidin... |
| Anwendung: | Tankyrase inhibitor |
| CAS | 1419949-20-4 |
| MW: | 494.6 D |
ab 78,00 €
