Zu "1403764-72-6" wurden 4 Artikel gefunden!
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PFI-1
Artikelnummer: TGM-T6222-100mg
Description: PFI-1 (PF-6405761), a specific BET (bromodomain-containing protein) inhibitor for BRD4, is with the IC50 of 0.22 µM in a cell-free assay. Target: Autophagy, Apoptosis, Epigenetic Reader Domain. Smiles: COc1ccccc1S(=O)(=O)Nc1ccc2NC(=O)N(C)Cc2c1. References: Fish PV, et al. J Med Chem, 2012, 55(22),...
| Schlagworte: | PFI 1, PFI1, PF-6405761 |
| Anwendung: | Bromodomain inhibitor |
| CAS | 1403764-72-6 |
| MW: | 347.39 D |
ab 43,00 €
PFI-1
Artikelnummer: Cay11155-1
Bromodomains recognize acetylated lysine residues and recruit regulatory complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. The isolated individual or tandem bromodomains of bromodomain-containing protein (BRD) 2 and BRD4 bind acetylated histone tails, which couples...
| Schlagworte: | PF-06405761, 2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide |
| Anwendung: | Bromodomain inhibitor |
| CAS | 1403764-72-6 |
| MW: | 347.4 D |
ab 53,00 €
MPI_5a
Artikelnummer: SYN-3040-M100
Solid. Soluble in DMSO. MPI_5a is a potent selective inhibitor of HDAC6. HDAC6 is a predominantly cytoplasmic enzyme that targets alpha-tubulin, cortactin and heat shock protein 90, and other substrates. MPI-5a has an IC50 of 36nM in tumour cell models and inhibits the acetylation of tubulin in cells with an IC50...
| Schlagworte: | MPI5a, N-Hydroxy-2-(1-methyl-1H-pyrrole-2-carbonyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide |
| Anwendung: | HDAC6 inhibitor |
| CAS | 1403764-72-6 |
| MW: | 299,3 D |
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PFI-1
Artikelnummer: LKT-P2133.1
PFI-1 is an inhibitor of BET bromodomains (BRDs) that prevents the association of BET with histones, it acts as an acyl-lysine (Kac) mimetic inhibitor, binding the Kac site of BRD2 and BRD4. PFI-1 exhibits anti-inflammatory and anticancer activities. In H202-treated bronchial epithelial cells, PFI-1 decreases...
| Schlagworte: | PF-06405761 |
| Anwendung: | Bromodomain inhibitor |
| CAS | 1403764-72-6 |
| MW: | 347.39 D |
ab 100,00 €
